ABSTRACT
There is no denying that the massive spread of COVID-19 around the world has worried everyone. The virus can cause mild to severe symptoms in various organs, especially the lungs. The virus affects oxidative stress in the cells. Reactive Oxygen Species modulator 1 (ROMO1) is one of the most important mitochondrial proteins that plays a critical regulatory role in the production of Reactive Oxygen Species (ROS). According to the studies, COVID-19 can promote oxidative stress through some important pathways, for instance, TNF-α and NF-κB routes. Furthermore, ROMO1 is closely related to these pathways and its dysfunction may affect these routes, then promote oxidative stress, and ultimately cause tissue damage, especially in the lungs. Another factor to consider is that the TNF-α and NF-κB pathways are associated with ROMO1, COVID-19, and oxidative stress. To summarize, it is hypothesized that COVID-19 may increase oxidative stress by affecting ROMO1. Understanding the exact molecular mechanisms of ROMO1 in the pathogenesis of COVID-19 can pave the way to find better therapeutic strategies.
ABSTRACT
Today, the incidence of cancer in the world is rising, and it is expected that in the next several decades, the number of people suffering from cancer or (the cancer rate) will double. Cancer is defined as the excessive and uncontrolled growth of cells; of course (in simple terms), cancer is considered to be a set of other diseases that ultimately causes normal cells to be transformed into neoplastic cells. One of the most important causes of the onset and exacerbation of cancer is excessive oxidative stress. One of the most important proteins in the inner membrane of mitochondria is Reactive Oxygen Species (ROS) Modulator 1 (ROMO1) that interferes with the production of ROS, and with increasing the rate of this protein, oxidative stress will increase, which ultimately leads to some diseases, especially cancer. In this overview, we use some global databases to provide information about ROMO1 cellular signaling pathways, their related proteins and molecules, and some of the diseases associated with the mitochondrial protein, especially cancer.
Subject(s)
Diagnosis , Incidence , Membranes , Mitochondria , Mitochondrial Proteins , Oxidative Stress , Reactive Oxygen SpeciesABSTRACT
Background and Aim: According to the recorded data on the Health Ministry database, a better understanding of clinical and epidemiological factors associated with ESRD can be helpful for decision making about the treatment and preventive interventions with the aim of public health promotion and development of health programs. This study aimed to evaluate the prevalence of ESRD and dialysis-related factors from 2000 to 2009
Material and methods: In this cross sectional study, data were obtained from specific diseases office of the Ministry of Health and Medical Education of the Islamic Republic of Iran from 2000 to 2009. There was no limitation on patient entry. Finally data were analyzed using SPSS software
Results: This study included 12797 patients [57.07% male and 42.57% female] from 2000 to 2009. The overall incidence of ESRD in men [compared to the gender distribution in the normal population] with a mean age of 58.8 [SD = 17.61] was higher in comparison to women. The most common etiologies were diabetes [25.5%], and hypertension [23.3%] respectively. There were no significant changes in diabetes and hypertension frequencies in the patients between 2000 and 2009. No significant relationship was found between blood groups and ESRD. Prevalence of anemia was higher in the women with ESRD and hemoglobin levels were directly correlated with educational status [P <0.001]
Conclusion: The incidence of ESRD has been on the increase during this study. Also we found a decrease in the middle and an increase at the end of the study in the prevalence of HIV which calls for further assessments